Scale Biosciences, Inc. (ScaleBioTM), an innovator in single cell sequencing leveraging combinatorial indexing applied sciences, immediately introduced an enlargement of their product portfolio to allow a broader vary of single cell omics experiments and unlock new translational analysis functions.
New merchandise embody the ScaleBio Single Cell Methylation Package, ScaleBio Single Cell CRISPR Information Enrichment Package, Scale-plex Package, and extra capabilities for the corporate’s present ScaleBio Single Cell RNA Sequencing Package to facilitate extra numerous experimental designs and broader use of translational samples leveraging revolutionary, scalable, and accessible instruments to democratize single cell omics throughout analysis functions with out the necessity for added instrumentation. Collectively, these kit-based merchandise broaden researchers’ capacity to profile cells and tissues, and to uncover novel cell varieties and states with their capabilities.
“Our new choices are a down cost on our dedication to democratizing single cell omics via improvements designed to redefine what’s doable throughout cell varieties, pattern throughput, and modalities of examine,” mentioned Giovanna Prout, chief govt officer at ScaleBio.
We stay up for our continued partnership with the analysis group which helps us establish one of the best methods to use our applied sciences to design merchandise that overcome technological limitations and handle market gaps.
Giovanna Prout, Chief Govt Officer, ScaleBio
ScaleBio is the primary single cell omics firm to supply its prospects an entire kitted answer for high-throughput single cell methylation sequencing. Constructing on the foundational work of educational researchers, ScaleBio constructed the ScaleBio Single Cell Methylation Sequencing Package to allow broader entry to single cell methylation instruments. The package makes use of a easy, instrument-free, plate-based indexing workflow leveraging ScaleBio’s patented combinatorial indexing expertise, to allow tasks profiling tens of 1000’s of cells. The corporate can be providing this answer as a service and is presently accepting new tasks.
Researchers throughout oncology, neuroscience, and different epigenetics functions can use this answer to organize sequencing-ready libraries from a variety of contemporary and frozen pattern varieties throughout species, powering new understandings of the connection between the genome and mobile operate. “The analysis group wants a sturdy answer to scale single cell methylation evaluation and assist unlock new understandings of the connection between genomics, epigenetics and human well being,” mentioned Andrew Adey, PhD, professor of molecular and medical genetics at Oregon Well being & Science College. “I’m happy to see the workforce at ScaleBio broaden upon my analysis and supply the group a kitted answer that allows simultaneous detection of DNA, and methylation standing on the single cell degree.”
ScaleBio additionally unveiled new single cell RNA-sequencing kits and capabilities designed to deal with the inherent limitations of present single cell genomics instruments and to permit its prospects to attain broader flexibility and extra sturdy information from their cell atlases. New kits and capabilities embody:
- ScaleBio Single Cell CRISPR Information Enrichment Package – This new package unlocks single cell CRISPR screening functions, additional bettering single cell CRISPR information detection with generally used CROP-seq libraries. The package helps pharmaceutical drug discovery functions together with goal and hit validation, in addition to illness analysis functions.
- Scale-plex Package – This package provides a brand new pattern multiplexing chemistry to allow translational researchers to conduct single cell RNA sequencing experiments utilizing small tissue samples equivalent to core needle biopsies, wonderful needle aspirates, and small tissue biopsies, that will in any other case be incompatible with this utility. Leveraging ScaleBio’s combinatorial indexing expertise and this new chemistry, researchers can pool samples whereas sustaining pattern id, restrict particular person pattern loss and reduce time spent on pattern and library preparation.
- Prolonged throughput capabilities – This addition to the ScaleBio Single Cell RNA Sequencing package permits prospects doing any sort of single cell RNA sequencing-based analysis to dramatically scale up their experiments from 125,000 cells to as much as 500,000 cells per run, whereas nonetheless utilizing ScaleBio’s instrument-free, single cell sequencing workflow.
“These new options present the broad applicability of ScaleBio’s single cell sequencing and combinatorial indexing expertise to deal with a variety of analysis questions, however extra importantly, they’re a testomony to our firm’s concentrate on addressing the shortcomings of present single cell genomics options in an accessible, scalable and cost-effective method,” mentioned Frank Steemers, PhD, cofounder and chief scientific officer at Scale Biosciences. “We stay up for sharing our spectacular product efficiency information at upcoming scientific conferences together with American Society of Human Genetics, and persevering with to companion with business leaders to develop extra cutting-edge merchandise that broaden the universe of what’s doable with single cell genomics.”
The ScaleBio Single Cell Methylation Sequencing Package, ScaleBio Single Cell CRISPR Information Enrichment Package and ScaleBio Prolonged Throughput Package can be found for order. All different merchandise shall be accessible for order by the top of 2023. For extra details about ScaleBio’s merchandise, go to www.scale.bio.
About Scale Biosciences
ScaleBio is a single-cell sequencing options firm based by a multidisciplinary workforce of scientists and technologists with mixed experience in next-generation sequencing, genomics, proteomics, and bioinformatics, and a typical mission for unlocking the potential of single-cell evaluation at scale by eliminating obstacles to discovery. ScaleBio is financed by main life sciences instruments buyers ARCH Enterprise Companions, BNG and Tao Capital. ScaleBio has R&D services in San Diego and San Carlos, Calif.