Anna Sjöström on the analysis group Experimental and Scientific Neuroendocrinology, the Division of Molecular Drugs and Surgical procedure, will defend her thesis “Extreme COVID-19 and routine biomarker patterns” on November 24, 2023. Her major supervisor is Charlotte Höybye.
What’s the principle focus of your thesis?
Sjöström: My thesis is concentrated on how ranges of a few of our routine blood exams are affected by extreme COVID-19. The main target is on patterns, dynamics and developments of routine blood exams. The three areas explored are coagulation, fluid stability and kidney operate.
That are an important outcomes?
Sjöström: The primary examine reveals that D-dimer ranges and platelet counts are key markers of severity in COVID-19. As every day imply platelet counts elevated and D-dimer ranges decreased over the examine interval, the thrombosis burden and deaths decreased. This coincided with the introduction of a better dose of anticoagulation for sufferers with extreme COVID-19.
In research II and III, hyponatremia was proven to be frequent at hospital admission for sufferers with extreme COVID-19. Nonetheless, it was additionally frequent to, over time, develop hypernatremia. Hypernatremia was extra frequent in extreme illness and was related to increased odds of loss of life.
Sufferers had completely different patterns and dynamics of different electrolytes and acid-base markers when divided into teams primarily based on the diploma of hypernatremia. Average/extreme COVID-19 was related to MR findings suggestive of a state of vasopressin depletion, in line with the event of hypernatremia attributable to central diabetes insipidus.
The final sub-study confirmed that it was frequent with variations between eGFR calculated with creatinine and Cystatin C in extreme COVID-19. The discrepancy was aggravated over the course of the illness, and a pronounced distinction was related to extreme illness and loss of life.
How can this new data contribute to the advance of individuals’s well being?
Sjöström: The direct profit is knowing how ranges and developments of a few of our commonest blood exams can be utilized to evaluate prognosis in sufferers with extreme COVID-19. The good thing about following developments and dynamics, even inside reference intervals, is a really useful discovering and prognostically helpful. This may be utilized to different knowledge supplies, which is fascinating for additional analysis.
What are your future ambitions?
Sjöström: I’ll proceed to mix my work as a specialist physician on the Karolinska College Laboratory with biomarker analysis the place routine blood exams have a central position. The dream is to have the ability to use our huge quantity of information, generated from routine blood samples, in an environment friendly method for prognosis, danger evaluation and analysis in a number of massive affected person teams.
Extra info:
Extreme COVID-19 and routine biomarker patterns. openarchive.ki.se/xmlui/deal with/10616/48787
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New thesis on extreme COVID-19 and routine biomarker patterns (2023, November 20)
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