Cornell College researchers have recognized a brand new method to harness the antioxidant and antibacterial properties of a botanical compound to make nanofiber-coated cotton bandages that struggle an infection and assist wounds heal extra shortly.
The findings are particularly vital given the growing prevalence of multidrug-resistant micro organism.
Cotton gauze is among the commonest wound dressings; it is cheap, available, snug and biocompatible. Nevertheless, it would not promote therapeutic or struggle an infection.
“Cotton alone can’t present a solution for these issues – it must be biofunctionalized,” mentioned lead writer Mohsen Alishahi, a doctoral scholar in fiber science who works within the NanoFibers and NanoTextiles (NanoFibTex) Laboratory.
Tamer Uyar, affiliate professor and the lab’s director, mentioned one in all its essential analysis pursuits is creating useful fibers from sustainable supplies and exploring their potential purposes in medical textiles and drug supply methods.
Researchers used lawsone, a red-orange compound present in henna leaves that has antioxidant, anti-inflammatory and antimicrobial properties, to spice up the efficiency of cotton.
The experimental dressing had wonderful antibacterial efficiency in opposition to gram-negative and gram-positive bacterial species, and successfully eradicated E. coli and staph micro organism in testing.
The extended overuse of artificial antibiotics in excessive concentrations has contributed to the rise of the lethal epidemic of multidrug-resistant microbes. So the usage of pure and potent anti-bacterials reminiscent of lawsone might function an alternative choice to artificial anti-bacterials.”
Tamer Uyar, Affiliate Professor, Cornell College
“Wound dressings ought to present an acceptable atmosphere for facilitating therapeutic and stopping an infection,” Alishahi mentioned. “Utilizing completely pure supplies reminiscent of cotton, cyclodextrin and lawsone, this dressing can facilitate each because it has complete antioxidant and anti-bacterial exercise.”
Alishahi mentioned that the dressing can be significantly useful for persistent wounds which can be extremely vulnerable to an infection, like diabetic ulcers and burns. The antioxidant and anti inflammatory properties would additionally profit extra routine wounds by lowering the formation of scars.
This analysis was funded by Cotton Included.
Alishahi, M., et al. (2024). Functionalization of cotton nonwoven with cyclodextrin/lawsone inclusion complicated nanofibrous coating for antibacterial wound dressing. Worldwide Journal of Pharmaceutics. doi.org/10.1016/j.ijpharm.2024.123815.