Instrument breaks the boundaries of EV detection, offering entry to new information factors.
Picture Credit score: Beckman Coulter Life Sciences
INDIANAPOLIS – (March 19, 2024) – Beckman Coulter Life Sciences, a world chief in laboratory automation and innovation and a subsidiary of Danaher Company (NYSE: DHR), continues to paved the way with first-to-market ideas with the launch of the CytoFLEX nano Stream Cytometer – the primary purpose-built nanoscale circulation cytometer for analysis use solely that permits detection to at the least 40 nm,* enabling 30-50% extra information creation in comparison with present market choices.
With unmatched sensitivity to detect, rely, and characterize nanoparticles utilizing a single analytical instrument, the CytoFLEX nano Stream Cytometer affords simultaneous multiparameter detection powered by six fluorescent detection channels and 5 aspect scatter channels.
It offers world laboratories with a first-of-its sort answer that lowers the restrict of detection and will increase decision to characterize decrease abundance targets in heterogeneous extracellular vesicle (EV) populations between 1 μm and 40 nm (polystyrene when triggering on violet aspect scatter).
“The CytoFLEX nano Stream Cytometer shatters the earlier limits of detection capabilities, arming researchers with information they beforehand would have by no means been capable of entry,” stated Product Supervisor Matthew Goff. “This may open new doorways for researchers and allow breakthrough discoveries in our battle in opposition to a myriad of ailments. Extracellular vesicles will be discovered in all places, and now researchers lastly have a device to see what has all the time been proper in entrance of them. We listened to the wants of our clients to create an analytical crossroads by growing sensitivity by enhanced fluidics, optics, and electronics.”
Picture Credit score: Beckman Coulter Life Sciences
Nanoparticles are launched in a hydrodynamic centered stream to the optical system composed of lasers and detectors. Emitted alerts are collected, digitized, and displayed by the electronics and instrument management software program, CytExpert. A number of automated on-board cleansing choices are supplied to manage sample-to-sample carryover and keep a clear pattern line.
“We have to go smaller to develop the realms of analysis, and there are only a few devices constructed for small particle detection alone,” stated Alfonso Blanco, Director of the Stream Cytometry Core Applied sciences within the College Faculty Dublin. “The CytoFLEX nano Stream Cytometer affords a gold mine of analysis discoveries, together with the flexibility to develop complicated biomarkers from blood or urine somewhat than extra invasive tissue means, which implies much less ache for sufferers, together with richer outcomes.”
The ergonomic design reduces noise, identifies backgrounds, and reduces carryover points. Constant instrument efficiency from intensive automated QC processes ensures constant and reproducible outcomes each time.
The platform additionally consists of the CytoFLEX, CytoFLEX S, and the CytoFLEX LX circulation cytometers, together with the CytoFLEX SRT cell sorter for analysis, and the DxFLEX circulation cytometer for diagnostic use. Be taught extra concerning the CytoFLEX nano instrument by clicking right here.
* Polystyrene when triggering on violet aspect scatter. For Analysis Use Solely (RUO), not to be used in diagnostic procedures.
About Beckman Coulter Life Sciences
With a relentless mission to empower these searching for solutions to life’s vital scientific questions, Beckman Coulter Life Sciences is a most popular laboratory associate offering automation and innovation options for Centrifugation, Stream Cytometry, Genomics, Particle Evaluation, and Liquid Dealing with workflows.
With a legacy relationship again to 1935, our applied sciences cut back handbook laboratory processes and may present larger velocity, accuracy, and superior analytics to speed up solutions with a guiding focus to enhance affected person care and allow pioneering discoveries. Beckman Coulter Life Sciences, a part of the Danaher Company (NYSE: DHR) household of world science and expertise firms, is headquartered in Indianapolis, Indiana with 11 operational hubs all over the world and employs roughly 2,800 associates with greater than 400,000 programs put in globally. Get to know us by clicking right here and by following us on LinkedIn.
