Prior research of uromodulin, essentially the most ample protein in urine, and kidney illness have centered totally on urinary uromodulin ranges. A examine, printed within the American Journal of Kidney Illnesses (AJKD), evaluated associations of serum uromodulin ranges with threat of end-stage kidney illness and mortality in a cohort of African American adults with hypertension and power kidney illness.
The analysis discovered that members with decrease ranges of uromodulin at baseline have been extra more likely to develop end-stage kidney illness, even after accounting for baseline kidney measures.
Equally, members who skilled steeper annual declines in uromodulin additionally had a heightened threat kidney failure. Neither baseline nor annual change in uromodulin was related to mortality. Ranges of uromodulin may be impacted by typical remedies, akin to intensive blood stress management and ramipril remedy. Serum uromodulin is a promising biomarker of kidney well being.
Extra data:
Teresa Okay. Chen et al, Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Outcomes From the African American Examine of Kidney Illness and Hypertension (AASK) Trial, American Journal of Kidney Illnesses (2023). DOI: 10.1053/j.ajkd.2023.05.017
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Nationwide Kidney Basis
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Uromodulin ranges might point out threat for kidney failure (2023, September 21)
retrieved 21 September 2023
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